Inferring a protein interaction map of Mycobacterium tuberculosis based on sequences and interologs
نویسندگان
چکیده
منابع مشابه
Inferring Protein-Protein Interactions Based on Sequences and Interologs in Mycobacterium Tuberculosis
Mycobacterium tuberculosis is a pathogenic bacterium that poses serious threat to human health. Inference of the protein interactions of M. tuberculosis will provide cues to understand the biological processes in this pathogen. In this paper, we constructed an integrated M. tuberculosis H37Rv protein interaction network by machine learning and ortholog-based methods. Firstly, we developed a sup...
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Specific protein-protein interactions are crucial in the cell, both to ensure the formation and stability of multiprotein complexes and to enable signal transduction in various pathways. Functional interactions between proteins result in coevolution between the interaction partners, causing their sequences to be correlated. Here we exploit these correlations to accurately identify, from sequenc...
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Background: Tuberculosis as a global health problem requires special attention in the contexts of prevention and control. Subunit vaccines are promising strategies to protect burdens of tuberculosis via increasing the BCG protection. The present study aimed to design a vaccine study by means of high-throughput expression and correct refolding of recombinant protein PPE17. Methods: We aimed to c...
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Tuberculosis remains a major public health problem in both developing and developed countries. Drug-resistant tuberculosis is an increasing health problem and serious challenge to tuberculosis (TB) control programs. Information about the susceptibility pattern of Mycobacterium tuberculosis isolates against anti-tuberculosis drugs is an important aspect to TB control. The objectives of the s...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2012
ISSN: 1471-2105
DOI: 10.1186/1471-2105-13-s7-s6